POLYNUCLEOTIDES Liverpool

Discover the revolutionary injectable that repairs, restores and revitalises your skin.

If your skin is feeling dull, tired, or lacking that healthy glow, polynucleotides could give you the boost your skin’s been waiting for. This next-generation injectable treatment is quickly becoming one of our most in-demand treatments for patients wanting brighter, smoother, and more resilient skin, especially in delicate areas like the under eyes. This treatment is designed to restore the skin rather than to fill or freeze. 

Whether you’re concerned about fine lines, under eyes, or post acne scarring, our expert aesthetic injectors will guide you through a personalised treatment plan to ensure you get the results you’re looking for. With minimal downtime and a high safety profile, polynucleotides are a great option for patients looking for a gentle yet highly effective skin refresh.

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Excellent work by Dr Charlotte, she listened and delivered exactly the look I wanted, gentle lifting in a few areas so no one would notice any difference, it looks so natural! Gentle tweaks for a fresher look, I couldn’t be happier! Thank you Dr Charlotte brilliant work! 👏👏

Tricia S.  |  2025

treatment times

Appointment length: 45 minutes

Results expected: Visible improvements within a week or two, with full results within 4-6 weeks

Results last: At least 6 months, oftentimes longer

Sessions required: Varies patient to patient, but usually 1-3 sessions

conditions treated

Tired, dull, or dehydrated skin: Polynucleotides deeply hydrate and stimulate cellular repair, restoring radiance and giving the skin a healthier, more luminous glow.

Fine lines or crepey skin: By boosting collagen and elastin production, polynucleotides help smooth fine lines and firm crepey areas like the under eyes and neck.

Textural irregularities: Polynucleotides encourage skin regeneration and fibroblast activity, improving overall skin texture and reducing roughness and enlarged pores.

treatment areas

Polynucleotides Under Eye

UNDER EYES

polynucleotides cheeks

CHEEKS

Décolletage

Neck/Chest

polynucleotides acne scars

ACNE SCARS

what are polynucleotides?

Polynucleotides are a type of injectable biostimulator made from fragments of purified DNA, typically derived from salmon. These DNA chains, known as polynucleotides, have regenerative properties that stimulate the skin’s natural healing processes. When injected into the skin, they activate fibroblasts. These are the cells responsible for producing collagen and elastin. 

When these fibroblasts are activated, it improves skin structure, hydration, and elasticity over time. They are different from dermal fillers, which add volume to the skin. Polynucleotides encourage your body to rebuild and restore skin quality from within. This is similar to how skin boosters work, but with a deeper focus on skin repair and regeneration rather than just hydration.

The great thing about polynucleotides is they’re suitable for a wide range of skin concerns, from fine lines and wrinkles to acne scarring and crepey under-eyes. Polynucleotides offer a gradual but noticeable improvement in skin health. Because this injectable treatment works at a cellular level, results develop over several weeks and tend to look more natural and subtle than dermal fillers.

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"I am very happy with my treatment! I get lots of compliments on how lovely and natural it looks."

Sarah C.

"They're amazing at what they do and pay so much attention to detail!"

Mia S.

"I can’t say enough good things about Smileworks."

Jane W.

"It’s a 5 star rating from me! Thank you for making me feel comfortable and safe 💓"

Brianna C.

polynucleotide benefits

polynucleotides skin regeneration

SKIN REGENERATION

Polynucleotides stimulate fibroblast activity, encouraging collagen and elastin production to repair and rejuvenate the skin.

polynucleotides deep hydration

DEEP HYDRATION

Polynucleotides attract and retain moisture within the skin, significantly improving hydration, elasticity, and plumpness.

polynucleotides natural results

NATURAL RESULTS

Unlike dermal fillers, polynucleotides don’t add volume, They work with your skin to improve texture and tone naturally over time.

polynucleotide treatment cost uk

We understand that investing in your skin can get expensive. That's why we keep our polynucleotide treatments competitvely priced, especially in comparison to other aesthetic treatments. In the UK, dermal fillers and more intensive skin treatments like ablative laser skin resurfacing provide great results, but they don’t fit everyone’s budget.

With polynucleotides, you can get a firmer, renewed skin complexion for the significantly less than the price for a single area of dermal filler. This isn't a bad price for the transformative effects of polynucleotides!

Polynucleotide Treatment (Associate Practitioner) | £275

Polynucleotide Treatment (Dr MJ) | £350

Polynucleotide Treatment - Course of 3 (Associate Practitioner) | £750

Polynucleotide Treatment - Course of 3 (Dr MJ) | £1000

your polynucleotide injectors

LEAD CLINICIAN
AESTHETIC DOCTOR
AESTHETIC NURSE PRESCRIBER

why choose smileworks?

Choosing where to get polynucleotides can be a big decision, but luckily Smileworks makes it easy. We are proud to be Liverpool’s leading polynucleotide clinic. Our patients are obsessed with this treatment, and they keep coming back. With the rapid rise of aesthetic complications in the UK, it’s never been more important to choose a reputable clinic that’s run by medical professionals.

At Smileworks, all of our clinicians and technicians are highly trained and experienced in what they do, so you can rest assured in their hands. We strive to offer safe yet effective treatment plans that will leave you with results to rave about.

smileworks liverpool

FAQ

Do polynucleotides work?

Yes, we’ve seen firsthand how polynucleotides transform our patients' skin. They are clinically proven to stimulate skin regeneration, improve hydration, and support collagen production. Some of our patients even report visible improvements in skin texture and elasticity after just one treatment.

How long do polynucleotides take to work?

You’ll typically notice a glow to your skin immediately after treatment, but optimal results typically develop over 3-6 weeks. Your skin needs time to heal and allow the regeneration process to take place.

Is one session enough?

Many of our patients see a noticeable difference in their skin after one session. However, some may need 3-4 sessions for more lasting results. These appointments are typically spaced 2-3 weeks apart. To maintain your results after this point, we recommend maintenance appointments every 6 months.

How long do results last?

Results typically last 6-9 months. Though, this largely depends on your skin condition, age, and lifestyle. Some may find their results last longer than this time, while others see their results fade more quickly. Maintenance treatments can help sustain the effects.

Is polynucleotide treatment worth it?

In our opinion, yes, polynucleotides are well worth it, especially for those looking to improve their skin quality at a cellular level. If you struggle with fine lines, skin hydration, or dark, hollow under eyes, we can assure you that polynucleotides are a worthwhile investment in long-term skin health.

Are polynucleotides safe?

Yes, polynucleotides have an excellent safety profile. They’re derived from purified DNA fragments (usually from salmon) and are biocompatible and well-tolerated. There is minimal risk of adverse reactions. All of our injectors at Smileworks come from medical backgrounds, so you can rest assured you’ll be in safe, capable hands. You may experience some post-treatment redness, bruising, or swelling, but this is all completely normal and should subside within a day or two.

Who is the ideal candidate? 

Polynucleotides are ideal for anyone experiencing signs of skin ageing, dehydration, dullness, or textural irregularities. They’re also a great option for patients who want natural-looking results without added volume.

Are polynucleotides better than Botox?

One isn’t better than the other. They both serve different purposes. Botox (though, at Smileworks we use Relfydess) is a toxin that relaxes the muscles to reduce dynamic wrinkles. Polynucleotide is an injectable that improves skin quality and elasticity over time. We find that many of our patients benefit from receiving both treatments, as Botox and polynucleotides work well in tandem.

Is polynucleotide a skin booster?

While polynucleotides and skin boosters are both injectables that aim to improve skin quality, they work in fundamentally different ways. Where skin boosters use hyaluronic acid to add moisture into the skin, polynucleotides use purified DNA fragments. The main goal of polynucleotides is repair and regenerate skin tissue on a cellular level. Polynucleotides are best for those with more advanced signs of ageing or skin damage.

Should I get polynucleotide under my eyes?

This is one of our patients’ favourite areas to get polynucleotides and is particularly effective in the under eyes. If you struggle with fine lines, crepey texture, or dark circles under your eyes, this is a great treatment to improve those concerns without any puffiness or volume-heavy effects that dermal fillers like tear trough filler can create.

Are polynucleotides painful?

Discomfort is extremely minimal. A fine needle or cannula is used, and numbing cream or local anesthetic is used beforehand. Most patients describe the treatment as tolerable with only slight pressure or stinging.

How do I book?

At Smileworks, we make booking easy! Use our online booking system to quickly schedule your consultation. If you prefer to book over the phone, you can give us a call at 0151 236 5166.

Any other questions?

No problem! Get in touch, and our friendly team will be happy to help. You can reach us with any additional questions at 0151 236 5166 or through email at tco@sexydentistry.com.

4.9
Based on 1663 reviews
I have been having Invisalign with Eduardo and Savannah. Absolutely amazing service. Friendly, comfortable and they have got my smile looking 10/10. Each time I go I am super relaxed and all runs super smooth.I have had a couple of bad dentistry experiences In life but it’s genuinely perfect at smileworks with these guys.It’s the right dentist to go to in Liverpool 😁
Sams L.
15:39 24 Oct 25
Exceptionnel service! I come in and it’s like going to see friends, you’re put at ease and lifted up! Such welcoming services from Emily, and Leah is just incredible shes helped me so much on my confidence journey, so professional making sure you are comfortable and understanding on what’s happening.
Erin-Joy L.
11:22 24 Oct 25
A big thank you to Eduardo for fitting my brace so perfectly! He’s both friendly and professional, which made the whole experience so much easier. The results have been fast and spot on, and I’m already seeing such a difference. I’m due to have my brace removed in October and can’t wait for the final outcome. One of my biggest insecurities has now disappeared, couldn’t be happier!Just had my brace removal and fixed retainer fitted by Kayleigh and Becca. I’m absolutely over the moon, the process was easy and pain free. Great vibes, appreciate the great work ❤️
Ellena M.
14:47 23 Oct 25
Khalid & Savannah were so lovely, made me feel at ease and gave judgement free treatment and care. My issues are already improving after a couple of visits and I couldn’t be happier.
Jennifer Q.
08:47 23 Oct 25
I had a brilliant experience at Smileworks. Eduardo was outstanding — professional, knowledgeable and incredibly reassuring throughout my visit. He took the time to explain everything clearly, answered all my questions and made me feel completely at ease. The treatment itself was gentle and precise, and I really appreciated his calm, confident manner. It’s rare to find someone who combines such expertise with genuine care, but Eduardo absolutely does. The whole team were friendly and efficient too, making the experience smooth from start to finish. Highly recommended.
Lisa K.
07:59 23 Oct 25
A massive thank you to Eduardo and Andreea for fitting my brace today! They were both extremely welcoming, friendly and professional and made me feel so at ease throughout the whole process.Eduardo explained everything very thoroughly and made sure to give me plenty of opportunities to ask any questions I had.Every visit here has been a positive one and this appointment didn't disappoint.I'm looking forward to seeing the results, after years of feeling self conscious of my teeth. 🙂
Leanne M.
17:12 21 Oct 25
Simple to book, enjoyed the pre-checks, now I'm ready to fly! (this makes sense as the practice is aviation inspired)I thoroughly enjoyed my consultation as a new patient today with Emma and Sav who took great care of me. Having had a couple of years out of minding my dental health, it was empowering to be included in the detailed conversation about the current state of my teeth and gums, with photos and xrays of my teeth displayed alongside other visuals used to help me understand what is going on! It felt great to be able to engage throughout this consultation compared to other practices I've used in the past where equipment felt dated and staff were not as informative and supportive. The practice looked clean and well equipped.Furthermore, it was nice to hear that I have good teeth visually, and incredibly beneficial to see that my current issues lie below the gums - something I wouldn't be aware of at home without my own radiology lab! I'm looking forward to starting treatment to conserve my teethies for another couple of decades!A huge thanks to the reception team who are a delight. Mushika and Rach were welcoming and attentive, and very helpful in booking me in and arranging finances for my future visits.I'm so happy to be flying with Smileworks!💪😎🌟
Tobias
12:40 21 Oct 25
Nearly at the end of a quite substantial amount of dental work at Smileworks and just had to come and leave a fabulous review for Samme and Helen. From the very beginning they have been brilliant, helping me choose between the options I had. I felt in no way pressured to choose a particular treatment and all the pros and cons were easily laid out for me to make my own decision. As for the actual treatments I've had the work spread out over about 6 appointments, so as not to overwhelm me. The quality of the work is first class and I certainly won't be going anywhere else now for any dental treatment. I'm over the moon with the work that's already been done and I go back next week for my final appointment for my final fit of porcelain veneers. I'd like to point out that I'm having the veneers and other work done as my teeth had weakened due to a medication I was taking. My main goal was to just have strong teeth again but Samme and Helen have made sure I'll be leaving with my most beautiful smile and I couldn't be happier. Id highly recommend them and the rest of the team at Smileworks Liverpool, so next time you need a check up or any dental work give them a call 😁 You definitely won't regret it 😁😁😁
Angie S.
14:43 19 Oct 25
I want to thank all the staff members who helped me on 14.10 allocating me on the emergency appointment. It was huge stress for me and fear of pain ( crown fell off exposing sensitive tooth ). Very special thanks to Rachael working at the reception desk who went above and beyond not only in finding the appointment time, but also show her care and empathy for the patient in distress. Her excellent listening skills and true engagement in helping others made me feel much better already when I started to speak with her. I realized later that I was asking the same questions, but she never show any impatience; replied in a kind,friendly and calm manner. Also, massive thanks to Emily who listened to my feedback and show her empathy and kindness.
H A.
16:55 17 Oct 25
Just been for my 1/2 year check ups with my Dentist JK and my hygiene and air flow, also got a filling today. Paula did teeth check and clean followed by my filling. No jab. I didnt feel a thing. Jo Paula's dental assistant was so very good, everything to hand and so gentle too. Great work girls. The receptionists mushika and Rach were very welcoming and sorted everything out for me. Thank you all 😊
Pauline L.
07:06 16 Oct 25
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