POLYNUCLEOTIDES Liverpool

Discover the revolutionary injectable that repairs, restores and revitalises your skin.

If your skin is feeling dull, tired, or lacking that healthy glow, polynucleotides could give you the boost your skin’s been waiting for. This next-generation injectable treatment is quickly becoming one of our most in-demand treatments for patients wanting brighter, smoother, and more resilient skin, especially in delicate areas like the under eyes. This treatment is designed to restore the skin rather than to fill or freeze. 

Whether you’re concerned about fine lines, under eyes, or post acne scarring, our expert aesthetic injectors will guide you through a personalised treatment plan to ensure you get the results you’re looking for. With minimal downtime and a high safety profile, polynucleotides are a great option for patients looking for a gentle yet highly effective skin refresh.

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Excellent work by Dr Charlotte, she listened and delivered exactly the look I wanted, gentle lifting in a few areas so no one would notice any difference, it looks so natural! Gentle tweaks for a fresher look, I couldn’t be happier! Thank you Dr Charlotte brilliant work! 👏👏

Tricia S.  |  2025

treatment times

Appointment length: 45 minutes

Results expected: Visible improvements within a week or two, with full results within 4-6 weeks

Results last: At least 6 months, oftentimes longer

Sessions required: Varies patient to patient, but usually 1-3 sessions

conditions treated

Tired, dull, or dehydrated skin: Polynucleotides deeply hydrate and stimulate cellular repair, restoring radiance and giving the skin a healthier, more luminous glow.

Fine lines or crepey skin: By boosting collagen and elastin production, polynucleotides help smooth fine lines and firm crepey areas like the under eyes and neck.

Textural irregularities: Polynucleotides encourage skin regeneration and fibroblast activity, improving overall skin texture and reducing roughness and enlarged pores.

treatment areas

Polynucleotides Under Eye

UNDER EYES

polynucleotides cheeks

CHEEKS

Décolletage

Neck/Chest

polynucleotides acne scars

ACNE SCARS

what are polynucleotides?

Polynucleotides are a type of injectable biostimulator made from fragments of purified DNA, typically derived from salmon. These DNA chains, known as polynucleotides, have regenerative properties that stimulate the skin’s natural healing processes. When injected into the skin, they activate fibroblasts. These are the cells responsible for producing collagen and elastin. 

When these fibroblasts are activated, it improves skin structure, hydration, and elasticity over time. They are different from dermal fillers, which add volume to the skin. Polynucleotides encourage your body to rebuild and restore skin quality from within. This is similar to how skin boosters work, but with a deeper focus on skin repair and regeneration rather than just hydration.

The great thing about polynucleotides is they’re suitable for a wide range of skin concerns, from fine lines and wrinkles to acne scarring and crepey under-eyes. Polynucleotides offer a gradual but noticeable improvement in skin health. Because this injectable treatment works at a cellular level, results develop over several weeks and tend to look more natural and subtle than dermal fillers.

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"I am very happy with my treatment! I get lots of compliments on how lovely and natural it looks."

Sarah C.

"They're amazing at what they do and pay so much attention to detail!"

Mia S.

"I can’t say enough good things about Smileworks."

Jane W.

"It’s a 5 star rating from me! Thank you for making me feel comfortable and safe 💓"

Brianna C.

polynucleotide benefits

polynucleotides skin regeneration

SKIN REGENERATION

Polynucleotides stimulate fibroblast activity, encouraging collagen and elastin production to repair and rejuvenate the skin.

polynucleotides deep hydration

DEEP HYDRATION

Polynucleotides attract and retain moisture within the skin, significantly improving hydration, elasticity, and plumpness.

polynucleotides natural results

NATURAL RESULTS

Unlike dermal fillers, polynucleotides don’t add volume, They work with your skin to improve texture and tone naturally over time.

polynucleotide treatment cost uk

We understand that investing in your skin can get expensive. That's why we keep our polynucleotide treatments competitvely priced, especially in comparison to other aesthetic treatments. In the UK, dermal fillers and more intensive skin treatments like ablative laser skin resurfacing provide great results, but they don’t fit everyone’s budget.

With polynucleotides, you can get a firmer, renewed skin complexion for the significantly less than the price for a single area of dermal filler. This isn't a bad price for the transformative effects of polynucleotides!

Polynucleotide Treatment (Associate Practitioner) | £275

Polynucleotide Treatment (Dr MJ) | £350

Polynucleotide Treatment - Course of 3 (Associate Practitioner) | £750

Polynucleotide Treatment - Course of 3 (Dr MJ) | £1000

your polynucleotide injectors

LEAD CLINICIAN
AESTHETIC DOCTOR
AESTHETIC NURSE PRESCRIBER

why choose smileworks?

Choosing where to get polynucleotides can be a big decision, but luckily Smileworks makes it easy. We are proud to be Liverpool’s leading polynucleotide clinic. Our patients are obsessed with this treatment, and they keep coming back. With the rapid rise of aesthetic complications in the UK, it’s never been more important to choose a reputable clinic that’s run by medical professionals.

At Smileworks, all of our clinicians and technicians are highly trained and experienced in what they do, so you can rest assured in their hands. We strive to offer safe yet effective treatment plans that will leave you with results to rave about.

smileworks liverpool

FAQ

Do polynucleotides work?

Yes, we’ve seen firsthand how polynucleotides transform our patients' skin. They are clinically proven to stimulate skin regeneration, improve hydration, and support collagen production. Some of our patients even report visible improvements in skin texture and elasticity after just one treatment.

How long do polynucleotides take to work?

You’ll typically notice a glow to your skin immediately after treatment, but optimal results typically develop over 3-6 weeks. Your skin needs time to heal and allow the regeneration process to take place.

Is one session enough?

Many of our patients see a noticeable difference in their skin after one session. However, some may need 3-4 sessions for more lasting results. These appointments are typically spaced 2-3 weeks apart. To maintain your results after this point, we recommend maintenance appointments every 6 months.

How long do results last?

Results typically last 6-9 months. Though, this largely depends on your skin condition, age, and lifestyle. Some may find their results last longer than this time, while others see their results fade more quickly. Maintenance treatments can help sustain the effects.

Is polynucleotide treatment worth it?

In our opinion, yes, polynucleotides are well worth it, especially for those looking to improve their skin quality at a cellular level. If you struggle with fine lines, skin hydration, or dark, hollow under eyes, we can assure you that polynucleotides are a worthwhile investment in long-term skin health.

Are polynucleotides safe?

Yes, polynucleotides have an excellent safety profile. They’re derived from purified DNA fragments (usually from salmon) and are biocompatible and well-tolerated. There is minimal risk of adverse reactions. All of our injectors at Smileworks come from medical backgrounds, so you can rest assured you’ll be in safe, capable hands. You may experience some post-treatment redness, bruising, or swelling, but this is all completely normal and should subside within a day or two.

Who is the ideal candidate? 

Polynucleotides are ideal for anyone experiencing signs of skin ageing, dehydration, dullness, or textural irregularities. They’re also a great option for patients who want natural-looking results without added volume.

Are polynucleotides better than Botox?

One isn’t better than the other. They both serve different purposes. Botox (though, at Smileworks we use Relfydess) is a toxin that relaxes the muscles to reduce dynamic wrinkles. Polynucleotide is an injectable that improves skin quality and elasticity over time. We find that many of our patients benefit from receiving both treatments, as Botox and polynucleotides work well in tandem.

Is polynucleotide a skin booster?

While polynucleotides and skin boosters are both injectables that aim to improve skin quality, they work in fundamentally different ways. Where skin boosters use hyaluronic acid to add moisture into the skin, polynucleotides use purified DNA fragments. The main goal of polynucleotides is repair and regenerate skin tissue on a cellular level. Polynucleotides are best for those with more advanced signs of ageing or skin damage.

Should I get polynucleotide under my eyes?

This is one of our patients’ favourite areas to get polynucleotides and is particularly effective in the under eyes. If you struggle with fine lines, crepey texture, or dark circles under your eyes, this is a great treatment to improve those concerns without any puffiness or volume-heavy effects that dermal fillers like tear trough filler can create.

Are polynucleotides painful?

Discomfort is extremely minimal. A fine needle or cannula is used, and numbing cream or local anesthetic is used beforehand. Most patients describe the treatment as tolerable with only slight pressure or stinging.

How do I book?

At Smileworks, we make booking easy! Use our online booking system to quickly schedule your consultation. If you prefer to book over the phone, you can give us a call at 0151 236 5166.

Any other questions?

No problem! Get in touch, and our friendly team will be happy to help. You can reach us with any additional questions at 0151 236 5166 or through email at tco@sexydentistry.com.

4.9
Based on 1651 reviews
Dr. Eduardo and his team are absolutely amazing! Every visit has been such a positive experience. I still remember being really nervous about getting my decayed tooth removed before starting my braces, but Dr. Eduardo went out of his way to make me feel comfortable — he played my favorite songs and hummed along to help me relax! It made such a difference and truly showed how much he cares about his patients. The whole team is super friendly, professional, the office is spotless, and the results are incredible — my smile has never looked better! I’m very impressed with the quality of treatment and attention to detail Dr. Eduardo provides. I highly recommend him to anyone seeking professional and friendly orthodontic treatment.
ya G.
11:21 08 Oct 25
I’ve only ever had really lovely experiences here, everyone is so friendly & kind!Emily is an absolute star, helped me through everything. Would highly recommend smileworks 🙂
Rachel S.
10:20 08 Oct 25
Liv and Mushika were very kind; they treated me very well when I went to the dental clinic, and I’m very satisfied with the service they provide to customers.🐱
Giacomo
10:09 08 Oct 25
smileworks is an excellent practice with excellent staff. dr kader aka jk is a consummate professional and an extremely skilled dentist. i have felt in safe hands through a long and sometimes arduous set of treatments entirely thanks to him. the other clinicians and front of house staff have also been top notch start to finish.
Robert L.
21:14 06 Oct 25
I was seen by Khadid and Jo, who were both excellent and explained everything for me to understand.Then I went to see Mushika to book further treatments, she too was excellent and patient as my diary was full.Highly recommend going to see Smileworks.
sean M.
16:04 06 Oct 25
First appointment today. Mushika and Marnie were super welcoming on the desk, putting me at ease instantly. JK and Liv were incredible, settling my nerves and talking me through everything openly and honestly. I’m so happy I chose to invest in myself at Smileworks!
Rebecca M.
14:31 06 Oct 25
Dr mj is amazing and very professional at what she does I feel so relaxed and know I am in excellent hands thankyou for all you have done for me will not go anywhere else highly recommend dr mj
Sarah Jane G.
15:09 03 Oct 25
Dr Zarmina & Jo were lovely & welcoming upon my recent appointment. I had composite bonding done and asked for it to look at natural as possible, I got exactly what I asked for. Would definitely recommend!
Jessica B.
11:21 03 Oct 25
Zarmina is the nicest dentist I’ve come across. really helpful and explains everything clearly. All staff really nice and welcoming especially reception. Never pressured into any treatments just explained your options. Recommend 10/10
Danny
08:37 03 Oct 25
Khal, Jo & Stef have been absolutely amazing!I had to get a cleaning done and a lot of fillings, it was so much work but they made me feel so comfortable and always made sure I was feeling okay.Ive always had bad experiences with the dentist and it made me quite scared of going but now I don't dread it anymore ♡Could not recommend more!
Emma K
20:44 01 Oct 25
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